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Multidrug tolerance
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Multidrug tolerance : ウィキペディア英語版
Multidrug tolerance

Multidrug tolerance or antibiotic tolerance is the ability of a disease-causing microorganism to resist killing by antibiotics or other antimicrobials. It is mechanistically distinct from multidrug resistance: It is not caused by mutant microbes, but rather by microbial cells that exist in a transient, dormant, non-dividing state. Microorganisms that display multidrug tolerance can be bacteria, fungi or parasites.
==Relevance to chronic infections==
Multidrug tolerance is caused by a small subpopulation of microbial cells termed persisters. Persisters are not mutants, but rather are dormant cells that can survive the antimicrobial treatments that kill the majority of their genetically identical siblings. Persister cells have entered a non- or extremely slow-growing physiological state which makes them insensitive (refractory or tolerant) to the action of antimicrobial drugs. When such persisting microbial cells cannot be eliminated by the immune system, they become a reservoir from which recurrence of infection will develop. Indeed, it appears that persister cells are the main cause for relapsing and chronic infections.〔 Chronic infections can affect people of any age, health, or immune status.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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